Source: CTD Holdings, Inc. 8/13/19
CTD Holdings, Inc. (OTCQB: CTDH), a clinical stage biopharmaceutical
company that develops cyclodextrin-based products for the treatment of
disease with unmet medical need, announced today that it has filed
supporting data for its patent application titled “Methods for Treating
Alzheimer’s Disease.” The original patent application was filed October
29, 2018 for the use of hydroxypropyl beta cyclodextrins in the
treatment of Alzheimer’s Disease. According to the US Centers for
Disease Control and Prevention, there were 5.7 million Americans living
with Alzheimer’s Disease in 2018.
“The data filed with the US Patent and Trademark Office are from a
single patient suffering from Alzheimer’s Disease who has been
intravenously using Trappsol® Cyclo™, our proprietary
hydroxypropyl beta cyclodextrin, for one year,” said N. Scott Fine,
CTD’s Chairman and CEO. The patient is using the drug on an expanded
access basis (see ClinicalTrials.gov NCT03624842).
“As reported to the FDA in a required annual report, the data suggest a
positive safety profile in this patient, overall stabilization of
disease, and improvement in certain behavioral aspects of the disease.”
The original patent application covers dosing regimens and routes of
administration. The patent application lists co-inventors Sharon H.
Hrynkow, PhD; Jeffrey L. Tate, PhD; and N. Scott Fine of CTD Holdings.
Hydroxypropyl beta cyclodextrins have been shown to decrease amyloid
beta, one of the hallmarks of Alzheimer’s disease, in animal and cell
culture studies, and to increase the memory span in a mouse model for
Alzheimer’s disease (see J. Yao et al., J. Exp. Med. 2012 vol
209(13):2501-13).
“There is currently no cure for Alzheimer’s Disease and only few
treatment options to address symptoms,” said Dr. Hrynkow, CTD’s Chief
Scientific Officer and Senior Vice President for Medical Affairs.
“Filing data in support of our patent application is an important step
forward as we begin development of this drug for an Alzheimer’s
indication.”
About CTD Holdings:
CTD Holdings, Inc. is a clinical-stage biotechnology company that
develops cyclodextrin-based products for the treatment of disease. The
company’s Trappsol® Cyclo™, an orphan drug designated product
in the United States and Europe, is used to treat Niemann-Pick Disease
Type C, a rare and fatal genetic disease, on a compassionate use basis
as well as in three ongoing formal clinical trials (Clinical Trials.gov NCT02939547, NCT02912793 and NCT03893071). Additional indications for the active ingredient in Trappsol® Cyclo™ are in development. For additional information, visit the company’s website: www.ctd-holdings.com
No comments:
Post a Comment